Publications
Virus Evolution
Molecular evolutionary dynamics, selective pressures, and transmission bottlenecks
Experimental evolution of an RNA virus in Caenorhabditis elegans
Identified genomic hotspots of nucleotide diversity important for Orsay virus evolution, establishing grounds for experimental virus evolution studies in nematodes.
A brief view on factors that affect plant virus evolution
Comprehensive minireview of key factors driving plant virus evolution.
Defects in plant immunity modulate the rates and patterns of RNA virus evolution
Different host defense signaling pathways constrain virus evolution in distinct ways.
Plant virus evolution under strong drought conditions results in a transition from parasitism to mutualism
Demonstrated that environmental stress can drive viruses to evolve beneficial relationships with their hosts, providing increased tolerance to adverse conditions.
Revisiting Orthotospovirus phylogeny using full-genome data
Updated phylogenetic analysis incorporating selection, recombination, and reassortment.
Adaptation of turnip mosaic potyvirus to a specific niche reduces its genetic and environmental robustness
Highly adapted viruses are more sensitive to random mutations and temperature changes than non-adapted viruses.
Role of host genetic diversity for susceptibility-to-infection in the evolution of virulence of a plant virus
Viruses specialize faster in homogeneous host populations but become more pathogenic in heterogeneous ones.
Mutagenesis scanning uncovers evolutionary constraints on tobacco etch potyvirus membrane-associated 6K2 protein
Revealed evolutionary tradeoffs between within-host viral accumulation and symptom severity.
Viral Impacts on Host Physiology
Developmental programs, metabolic homeostasis, and aging processes
Viral infections reduce Drosophila lifespan through accelerated aging
Enteric viral infections trigger irreversible aging processes that persist even after infection clearance, correlating with reduced lifespan.
Persistent viral infections impact key biological traits in Drosophila melanogaster
Comprehensive characterization of how persistent viral infections affect insect biology.
Transcriptional and hormonal profiling uncovers plant development-virus interactions
Plants downregulate cell wall genes to facilitate viral spread but maintain fertility through salicylic acid-mediated resistance tradeoffs.
Host developmental stages shape the evolution of a plant RNA virus
TuMV evolution differs across three developmental stages of Arabidopsis thaliana.
Viral strain-dependent impact of plant developmental stages on interaction networks
Ancestral viral adaptation history influences future evolution under developmental constraints.
From foes to friends: viral infections expand host phenotypic plasticity
Review: viruses can enhance host survival under environmental stress by altering phenotypic plasticity.
Genetic Architecture of Host-Virus Interactions
Genetics of antiviral immunity and susceptibility factors
Genetic basis of Arabidopsis thaliana responses to turnip mosaic virus
Identified genetic underpinnings of plant resistance to naïve and adapted viral isolates.
Caenorhabditis elegans immune responses to intracellular pathogens
Review of nematode responses to microsporidia and viruses.
C. elegans pharynx mutants resist Orsay virus infection
Identified specific mutants conferring viral resistance.
GWAS identifies Arabidopsis genes affecting TuMV infection outcomes
Genome-wide study revealing new host genes involved in plant defense and virus replication.
Environmental Modulation of Host-Virus Interactions
Impact of abiotic factors and microbiome on infection dynamics
Microgravity and low muon radiation affect viral pathogenesis in C. elegans
Space-like conditions impact fecundity and developmental success in infected animals.
Natural monobacterial environments modulate viral infection in C. elegans
Natural bacteria reduce viral susceptibility through novel DRH-1-dependent mechanisms without degrading virions or affecting nutrition.
The interplay between the host microbiome and pathogenic viral infections
Integrative review of microbiome impacts on viral infections across pathosystems.
Other Contributions
Additional research and scientific communications
Institut Pasteur Virology Days meeting report
Report on the Journées Départementales de Virologie at Institut Pasteur.
Natural variation in Arabidopsis rosette area unveils new developmental genes
GWAS identifying new genes involved in plant growth.
The scale-of-choice effect in assortative mating estimates
Sampling biases affect observations of negative assortative mating frequency.
Updated January 2025